Hepatocellular Carcinoma: Methods and Protocols (Methods in Molecular Medicine)
Hepatocellular Carcinoma: Methods and Protocols (Methods in Molecular Medicine) by Nagy A. Habib

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Author: Nagy A. Habib
Title: Hepatocellular Carcinoma: Methods and Protocols (Methods in Molecular Medicine)
ISBN: 0896037851
ISBN13: 978-0896037854
Other Formats: doc txt mbr docx
Pages: 302 pages
Publisher: Humana Press; 2000 edition (May 10, 2000)
Language: English
Size PDF version: 1574 kb
Size EPUB version: 1547 kb
Category: Medical Books
Subcategory: Medicine

Hepatocellular Carcinoma: Methods and Protocols outlines the research methods applied in the laboratories and clinics of those scientists and cli- cians interested in the understanding and clinical management of patients with hepatocellular carcinoma (HCC). Part I, The Clinical Problem, has been contributed by two leading cli- cal groups who have identified and addressed problem areas related to the management of HCC patients. Various treatment modalities are discussed and emphasis is placed on the limitations they experienced. Part II, HCC Carcinogenesis, reviews the main etiological factors related to hepatitis B and hepatitis C. Part III, Molecular and Biological Characteristics, provides insight into the molecular changes associated with HCC, including tumor-suppressor genes, oncogenes, adhesion molecules, matrix metalloproteinase, and novel genes and markers. Part IV, HCC Gene Therapy, addresses gene therapy approaches to treating hepatocellular carcinoma. It includes the use of various vectors, such as lipids, viruses such as adenoviruses and baculoviruses, and virus detection using el- tron microscopy assessment. The use of adenovirus with specific promotors, such as AFP, is also included. Preclinical and clinical data on the killing of cancer cells using tumor-suppressor genes, antisense to growth factors, immunogene therapy, or virus-directed enzyme prodrug therapy are addressed.

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